Recently published papers:
These are recent publications, from the year 2002 to current papers in preparation. If the there is a link to a .pdf file, any comments would be greatly appreciated and will be used to improve the text before submission to publication. When accepted for publication the paper will be removed from this site. Address comments to cohn@salk.edu.

2002

1. Langman, R.E. and Cohn, M. (2002) Introduction: haplotype exclusion at the immunoglobulin loci: what, how and why. Sem. Immunol. 14:141-142

2. Langman, R.E. and Cohn, M. (2002) Missing views on haplotype exclusion. Sem. Immunol. 14:143-144.

3. Langman, R.E. and Cohn, M. (2002) Haplotype exclusion: the solution to a problem in natural selection. Sem. Immunol. 14:153-162.

4. Cohn, M. and Langman, R.E., Editors (2002) Editorial closing commentary; Haplotype and Isotype Exclusion: How and Why? Sem. Immunol. 14:247.

5. Cohn, M. and Langman, R.E. (2002) To be or not to be ridded? – that is the question addressed by the Associative Antigen Recognition Model. Scand. J. Immunol. 55:318-323.

6. Cohn, M. (2002) The immune system: a weapon of mass destruction invented by evolution to even the odds during the war of the DNAs. Immunol. Reviews 185:24-38.

7. Langman, R.E. and Cohn, M. (2002) If the immune repertoire is large, random, and somatically generated, then.... Cell. Immunol. 216:15-22.

8. Cohn, M., Langman, R.E. and Mata, J. (2002) A computerized model for the self-nonself discrimination at the level of the T-helper (Th genesis) I. The origin of “primer” effector T-helpers. Intl. Immunol. 14:1105-1112.

9. Licon Luna, R.M., Lee, E., Müllbacher, A., Blanden, R.V., Langman, R. and Lobigs, M. (2002) Lack of both Fas ligand and perforin protects from flavivirus-mediated encephalitis in mice. J. Virol. 76:3202-3211.

10. Cohn, M. (2002) Rodney Eric Langman: In Memoriam. Scand. J. Immunol. 56:665-666

2003

11. Langman, R.E., Mata, J. and Cohn, M. (2003) A computerized model for the self-nonself discrimination at the level of the T-helper (Th genesis) II. The behavior of the system upon encounter with nonself antigens. Intl. Immunol. 15:593-609.

12. Cohn, M. (2003) Tritope model of restrictive recognition by the TCR. Trends in Immunol. 24:127-131.

13. Cohn, M. (2003) Does complexity belie a simple decision-on the Efroni and Cohen critique of the minimal model for a self-nonself discrimination. Cell. Immunol. 221:138-142.

2004

14. Cohn, M. (2004) Distinguishing the Tritope from the Interaction Antigen models. Trends in Immunology 25:8-9.

15. Cohn, M. (2004) An alternative to current thinking about positive selection, negative selection and activation of T-cells. Immunol. 111:375-380. PMCID: 1782434

16. Cohn, M. (2004) If the “adaptive” immune system can recognize a significant portion of the pathogenic universe to which the “innate” immune system is blind, then... Scand. J. Immunol. 60:1-2. PMCID: 1360149

17. Cohn, M. (2004) A response to Dembic: does the immune system reject the harmful, protect the useful and neglect the rest? Scand. J. Immunol. 60:6-7.

18. Cohn, M. (2004) Whither T-suppressors: If they didn’t exist would we have to invent them? Cell. Immunol. 227:81-92.

2005

19. Cohn, M. (2005) Degeneracy, Mimicry and Crossreactivity in Immune Recognition. Mol. Immunol. 42:651-655.

20. Cohn, M. (2005) A biological context for the Self-Nonself discrimination and the regulation of effector class by the immune system. Immunol. Res. 31:133-150.

21. Cohn, M. (2005) The common sense of the Self-Nonself discrimination. Springer Seminars in Immunopathology 27:3-17.

22. Cohn, M. (2005) The Tritope model for restrictive recognition of antigen by T-cells: I. What assumptions about structure are needed to explain function? Mol. Immunol. 42:1419-1443.

23. Cohn, M. (2005) A commentary on the Zinkernagel-Hengartner “Credo 2004.” Scand. J. Immunol. 61:477-484.

24. Cohn, M. (2005) On the Responses of Zinkernagel & Hengartner: An invitation to join the fray. Scand. J. Immunol. 62:99-102.

2006

25. Cohn, M. (2006) What are the commonalities governing the behavior of immune recognitive repertoires? Dev. & Comp. Immunol. 30:19-42.

26. Cohn, M. (2006) On the logic of Positive Selection. Immunology 117:452-453. PMCID: 1782246

27. Cohn, M. (2006) On “Credo 2004” as viewed under the “Development-Context” Model of Colin Anderson. Scan. J. Immunol. 64:97-103.

28. Cohn, M. (2006) Does the signal for the activation of T cells originate from the antigen-presenting cell or the effector T-helper? Cell. Immunol. 241:1-6. PMCID: 1828112

2007

29. Cohn, M. (2007) Conceptualizing the Self-Nonself discrimination by the vertebrate immune system. In: In Silico Immunology. eds. J. Timmis and D. Flower, Springer, New York, p. 375-398.

30. Mata, J. and Cohn, M. (2007) Cellular Automata-Based Modeling Program: synthetic immune system. Immunol. Revs., 216:198-212.

31. Cohn, M. (2007) On a Key Postulate of TCR restrictive function: The V-gene loci act as a single pool encoding recognition of the polymorphic alleles of the species MHC. Immunol. 120:140-142.

32. Cohn, M. and Mata, J. (2007) Introduction: Quantitative modeling of immune responses. Immunol. Revs. 216:5-8. http:www.blackwell-synergy.com/doi:10.1111/j.1600-065X.2006.00492.x

33. Cohn, Melvin, Mitchison, N. Av, Paul, William E., Silverstein, Arthur, M., Talmage, David W. and Weigert, Martin (2007) Viewpoint: Reflections on the clonal-selection theory. Nature Reviews Immunology 7:823-830.

34. Cohn, M. (2007) Editorial: "Breakthroughs in Immunology." Eur. J. Immunol. 37:S1-2.

2008

35. Cohn, M. and Mata, J. (2008) Introduction: Theories and Modelling of T Cell Behaviour. Mol. Immunol. 45:581.

36. Cohn, M. (2008) The Tritope Model For Restrictive Recognition of Antigen by T Cells: II. Implications for ontogeny, evolution and physiology. Mol. Immunol. 45:632-652.

37. Cohn, M. (2008) An in depth analysis of the concept of "polyspecificity" assumed to characterize TCR/BCR recognition. Immun. Res. 40:128-147.

38. Cohn, M. (2008) What does the T-cell recognize when it docks on an MHC-encoded restricting element? Mol. Immunol. in press.


Last updated March 3, 2008